Leptin, a hormone secreted by adipose tissue, plays a crucial role in regulating metabolism and energy balance. It influences appetite, energy expenditure, and metabolic processes, impacting overall health and body weight regulation. Leptin resistance, often seen in obesity, complicates its effectiveness, leading to metabolic disorders.
Leptin's Role
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Leptin is the body's energy regulator
Leptin is an *adipocyte-derived hormone* that acts as a key regulator of metabolism and energy balance. [It is primarily secreted by fat cells and circulates in proportion to body energy stores](https://pubmed.ncbi.nlm.nih.gov/12614978/). Leptin's primary role is to signal the brain about the body's energy status, [helping to regulate hunger and energy expenditure](https://my.clevelandclinic.org/health/articles/22446-leptin). By binding to receptors in the hypothalamus, [leptin influences the activity of neurons that control appetite and energy balance](https://www.ncbi.nlm.nih.gov/books/NBK537038/).
Energy Balance
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Metabolic Effects
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Obesity and Resistance
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